By measuring activation of the insulin receptor and two enzymes in the pathway, the authors showed that NNC2215 stimulated receptor signalling in cultured cells. Other experiments revealed that ...

The binding of Ht proteins to the insulin receptor activates the same signaling pathways as insulin. This activation leads to enhanced macropinocytosis (cellular uptake), allowing more Ht proteins ...

A modified insulin that can prevent sudden drops in ... experienced by individuals with diabetes), the NNC2215 insulin receptor affinity increased by 3.2-fold, validating its potential to respond ...