Frascati is a city and comune in the Metropolitan City of Rome Capital in the Lazio region of central Italy. It is located 20 kilometres south-east …Frascati is a city and comune in the Metropolitan City of Rome Capital in the Lazio region of central Italy. It is located 20 kilometres south-east of Rome, on the Alban Hills close to the ancient city of Tusculum. Frascati is closely associated with science, being the location of several international scientific laboratories.